A pseudotyped HIV-1 virus was utilized to explore the anti-HIV-1 activity of Dandelion. The level of HIV-1 replication was assessed by the percentage of GFP-positive cells. The inhibitory effect of the dandelion extract on reverse transcriptase activity was assessed by the reverse transcriptase assay kit.
Compared to control values obtained from cells infected without treatment, the level of HIV-1 replication and reverse transcriptase activity were decreased in a dose-dependent manner. The data suggests that dandelion has a potent inhibitory activity against HIV-1 replication and reverse transcriptase activity.
Dandelion showed strong activity against HIV-1 RT and inhibited both the HIV-1 vector and the hybrid-MoMuLV/MoMuSV retrovirus replication. These findings provide additional support for the potential therapeutic efficacy of Dandelion (Taraxacum officinale). This could be the beginnings of an antiretroviral therapy with fewer side effects.
Huamin Han, Wen He, Wei Wang and Bin Gao
BMC Complementary and Alternative Medicine
2011, 11:112dol:10.1186/1472-6882-11-112
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